2. Signaling Pathways
  3. GPCR/G Protein
  4. P2Y Receptor

P2Y Receptor

P2Y Receptor

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P2Y receptors are a class of G protein-coupled receptors (GPCRs) activated by extracellular nucleotides (ATP, UTP, and UDP). There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). The P2Y receptors are expressed in various cell types and play important roles in physiology and pathophysiology including inflammatory responses and neuropathic pain.

The P2Y family can be further divided into a subfamily of five P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs (“P2Y1-like”) that stimulate phospholipase C (PLC) through Gq protein and a second subfamily of P2Y12, P2Y13, and P2Y14Rs (“P2Y12-like”) that inhibit adenylate cyclase through Gi protein. Other effector pathways have been documented, such as coupling of the P2Y11R to Gs as well as to Gq in some cells to induce stimulation of cyclic AMP production.

P2Y Receptor Isoform Specific Products:

P2Y Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-108661
    NF546
    		Agonist
    NF546 is a selective non-nucleotide P2Y11 agonist with a pEC50 of 6.27. NF546 stimulates release of interleukin-8 from human monocyte-derived dendritic cells.
    NF546
  • HY-100254
    TAK-024
    		Inhibitor
    TAK-024 is a platelet inhibitor with IC50s of 31, 79 and 51 nM in human, monkey and guinea pig, respectively.
    TAK-024
  • HY-RS09931
    P2RY4 Human Pre-designed siRNA Set A
    		Inhibitor

    P2RY4 Human Pre-designed siRNA Set A contains three designed siRNAs for P2RY4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2RY4 Human Pre-designed siRNA Set A
  • HY-D1199
    Blue FPG-A trisodium
    		Antagonist
    Blue FPG-A trisodium is a selective antagonist of P2X1 receptor and P2Y1 receptor with IC50 values of 35.5 μM and 2.6 μM, respectively. Blue FPG-A trisodium is a structural isomer of the components of Reactive Blue 2 (RB2).
    Blue FPG-A trisodium
  • HY-108651
    Uridine-5'-O-3-thiotriphosphate trisodium
    		Agonist
    Uridine-5'-O-(3-thiotriphosphate) trisodium, a stable analogue of UTP, is a potent agonist of the P2Y2 and P2Y4 receptors with increased metabolic stability.
    Uridine-5'-O-3-thiotriphosphate trisodium
  • HY-17459R
    Clopidogrel hydrogen sulfate (Standard)
    		Inhibitor
    Clopidogrel (hydrogen sulfate) (Standard) is the analytical standard of Clopidogrel (hydrogen sulfate). This product is intended for research and analytical applications. Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor.
    Clopidogrel hydrogen sulfate (Standard)
  • HY-179133
    HDB-1
    		Inhibitor 98.02%
    HDB-1 is a selective inhibitor of the P2Y14 receptor (P2Y14R) with an IC50 of 26 pM. HDB-1 shows no significant inhibition on P2Y1R, P2Y2R, P2Y4R, P2Y6R, and P2Y12R. HDB-1 blocks the activation of hepatic stellate cells (HSC) by inhibiting the PKA/Raf1/MEK/ERK signaling pathway mediated by P2Y14R, thereby alleviating the core pathological process of liver fibrosis. HDB-1 can be used for the study of liver fibrosis.
    HDB-1
  • HY-167855S
    1’-Epi Gemcitabine hydrochloride-13C,15N2
    1’-Epi Gemcitabine hydrochloride-13C,15N2 is the 13C- and 15N-labeled MRS4833 (HY-167855). MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with an of IC50 of 5.92 nM for hP2Y14R and an IC50 of 4.8 nM for mP2Y14R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model.
    1’-Epi Gemcitabine hydrochloride-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-146499
    Antiplatelet agent 2
    		Inhibitor
    Antiplatelet agent 2 (compound 7p) is a Ticagrelor analoguehas, possessing antiplatelet activity. Antiplatelet agent 2 can be used for researching platelet aggregation.
    Antiplatelet agent 2
  • HY-110265
    SAR216471 hydrochloride
    		Antagonist
    SAR216471 hydrochloride is a P2Y12 receptor antagonist. SAR216471 hydrochloride has antiplatelet and antithrombotic activities in vivo.
    SAR216471 hydrochloride
  • HY-156220
    MRS4654
    		Inhibitor
    MRS4654 is an efficient and neutral P2Y14R (hP2Y14R IC50 = 15.0 nM, mP2Y14R IC50 = 18.6 nM) antagonist. MRS4654 has analgesic and anti-inflammatory effects. MRS4654 can be used for research on asthma and neuropathic pain.
    MRS4654
  • HY-120612
    BMS-884775
    		Antagonist
    BMS-884775 is a selective and orally active P2Y1 antagonist with an IC50 of 0.1 nM for the human P2Y1 receptor. BMS-884775 has a similar efficacy in preventing arterial thrombosis to Clopidogrel (HY-15283) and Prasugrel (HY-15284), but treatment with BMS-884775 results in shorter bleeding time and lower bleeding risk. BMS-884775 can be used in research related to antiplatelet and arterial thrombosis-associated diseases.
    BMS-884775
  • HY-178006
    MRS4917
    		Antagonist
    MRS4917 is an orally active, potent selective P2Y14 receptor (hP2Y14R) antagonist (IC50 = 2.88 nM, Ki = 1.67 nM) that shows >18,000 fold selectivity against P2Y6R (IC50 = 54 μM). MRS4917 demonstrates oral efficacy in reversing established mechanoallodynia in the chronic constriction injury (CCI) mouse model, while having no effect on thermoregulation. MRS4917 can be used for neurological diseases research.
    MRS4917
  • HY-134361
    ATP-γ-S tetrasodium
    		Agonist
    ATP-γ-S (tetrasodium) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATP-γ-S (tetrasodium) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATP-γ-S (tetrasodium) is active in ATP hydrolysis.
    ATP-γ-S tetrasodium
  • HY-174153
    PSB-22219
    		Ligand
    PSB-22219 is a highly selective non-nucleotidic ligand acting on P2Y12 receptors (KD=4.57 nM). PSB-22219 is promising for research of P2Y12 receptor-associated neuroinflammation.
    PSB-22219
  • HY-177726
    UTPU trisodium
    		Agonist
    UTPU trisodium (Compound 19) is a selective P2Y6R agonist with an EC50 of 0.4 μM. UTPU trisodium can activate the intracellular calcium signaling pathway mediated by P2Y6. UTPU trisodium can be used for the research of inflammation.
    UTPU trisodium
  • HY-115273
    MRS-2179
    		Antagonist
    MRS-2179 is a selective and competitive antagonist for P2Y1 receptor, with KB of 0.177 μM.
    MRS-2179
  • HY-RS09929
    P2ry2 Mouse Pre-designed siRNA Set A
    		Inhibitor

    P2ry2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2ry2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry2 Mouse Pre-designed siRNA Set A
  • HY-RS09928
    P2RY2 Human Pre-designed siRNA Set A
    		Inhibitor

    P2RY2 Human Pre-designed siRNA Set A contains three designed siRNAs for P2RY2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2RY2 Human Pre-designed siRNA Set A
  • HY-W686186
    Prasugrel hydroxy thiolactone
    		Control
    Prasugrel hydroxy thiolactone (compound M18) is a metabolite of Prasugrel (HY-15284). Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits Adenosine 5'-diphosphate (ADP, HY-W010918)-induced platelet aggregation.
    Prasugrel hydroxy thiolactone
Cat. No. Product Name / Synonyms Application Reactivity
P2Y Receptor Isoform Comparison

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