P2Y Receptor
P2Y receptors are a class of G protein-coupled receptors (GPCRs) activated by extracellular nucleotides (ATP, UTP, and UDP). There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). The P2Y receptors are expressed in various cell types and play important roles in physiology and pathophysiology including inflammatory responses and neuropathic pain.
The P2Y family can be further divided into a subfamily of five P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs (“P2Y1-like”) that stimulate phospholipase C (PLC) through Gq protein and a second subfamily of P2Y12, P2Y13, and P2Y14Rs (“P2Y12-like”) that inhibit adenylate cyclase through Gi protein. Other effector pathways have been documented, such as coupling of the P2Y11R to Gs as well as to Gq in some cells to induce stimulation of cyclic AMP production.
P2Y Receptor Isoform Specific Products
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P2Y Receptor Inhibitors
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P2Y Receptor Agonists
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P2Y Receptor Antagonists
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P2Y Receptor Activators
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P2Y Receptor Modulators
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P2Y Receptor Controls
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P2Y Receptor Ligands
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P2Y Receptor Related Products (229)
Related Products (229)
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Antibodies (2)
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P2Y Receptor Isoform Comparison
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Uridine 5'-diphosphate-d12 dilithium
0 ImagesCat. No.: HY-113359ASSynonyms: UDP-d12 dilithiumUridine 5'-diphosphate-d12 (UDP-d12) dilithium is the d12-labeled Uridine 5'-diphosphate (HY-113359). Uridine-5'-diphosphate is an important nucleotide made of uracil, ribose, and a pyrophosphate group. Uridine-5'-diphosphate is a potent, selective human P2Y6 receptor native agonist (EC50 = 300 nM; pEC50 = 6.52). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.
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TAK-024
0 ImagesCat. No.: HY-100254CAS No.: 186971-69-7TAK-024 is a platelet inhibitor with IC50s of 31, 79 and 51 nM in human, monkey and guinea pig, respectively.
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P2RY4 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09931P2RY4 Human Pre-designed siRNA Set A contains three designed siRNAs for P2RY4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Blue FPG-A trisodium
0 ImagesCat. No.: HY-D1199CAS No.: 78617-94-4Blue FPG-A trisodium is a selective antagonist of P2X1 receptor and P2Y1 receptor with IC50 values of 35.5 μM and 2.6 μM, respectively. Blue FPG-A trisodium is a structural isomer of the components of Reactive Blue 2 (RB2).
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Uridine-5'-O-3-thiotriphosphate tetrasodium
0 ImagesCat. No.: HY-137603ASynonyms: UTPγS tetrasodiumUridine-5'-O-(3-thiotriphosphate) (UTPγS) tetrasodium, a stable analogue of Uridine triphosphate (UTP) (HY-107372), is a potent agonist of the P2Y2 and P2Y4 receptors with increased metabolic stability. Uridine-5'-O-(3-thiotriphosphate) tetrasodium stimulates inositol phosphate formation in human 1321N1 astrocytoma cells stably expressing the phospholipase C-coupled human P2U-purinoceptor (EC50 = 240 nM).
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Uridine-5'-O-3-thiotriphosphate trisodium
0 ImagesCat. No.: HY-108651CAS No.: 1266569-94-1Synonyms: UTPγS trisodiumUridine-5'-O-(3-thiotriphosphate) trisodium, a stable analogue of UTP, is a potent agonist of the P2Y2 and P2Y4 receptors with increased metabolic stability.
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Clopidogrel hydrogen sulfate (Standard)
0 ImagesSynonyms: (S)-(+)-Clopidogrel bisulfate (Standard); (S)-(+)-Clopidogrel hydrogen sulfate (Standard)Clopidogrel (hydrogen sulfate) (Standard) is the analytical standard of Clopidogrel (hydrogen sulfate). This product is intended for research and analytical applications. Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor.
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HDB-1
0 ImagesHDB-1 is a selective inhibitor of the P2Y14 receptor (P2Y14R) with an IC50 of 26 pM. HDB-1 shows no significant inhibition on P2Y1R, P2Y2R, P2Y4R, P2Y6R, and P2Y12R. HDB-1 blocks the activation of hepatic stellate cells (HSC) by inhibiting the PKA/Raf1/MEK/ERK signaling pathway mediated by P2Y14R, thereby alleviating the core pathological process of liver fibrosis. HDB-1 can be used for the study of liver fibrosis.
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1’-Epi Gemcitabine hydrochloride-13C,15N2
0 ImagesCat. No.: HY-167855S1’-Epi Gemcitabine hydrochloride-13C,15N2 is the 13C- and 15N-labeled MRS4833 (HY-167855). MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with an of IC50 of 5.92 nM for hP2Y14R and an IC50 of 4.8 nM for mP2Y14R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model.
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Antiplatelet agent 2
0 ImagesCat. No.: HY-146499CAS No.: 1395047-93-4Antiplatelet agent 2 (compound 7p) is a Ticagrelor analoguehas, possessing antiplatelet activity. Antiplatelet agent 2 can be used for researching platelet aggregation.
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SAR216471 hydrochloride
0 ImagesCat. No.: HY-110265CAS No.: 1279829-64-9SAR216471 hydrochloride is a P2Y12 receptor antagonist. SAR216471 hydrochloride has antiplatelet and antithrombotic activities in vivo.
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MRS4654
0 ImagesCat. No.: HY-156220CAS No.: 2765570-58-7MRS4654 is an efficient and neutral P2Y14R (hP2Y14R IC50 = 15.0 nM, mP2Y14R IC50 = 18.6 nM) antagonist. MRS4654 has analgesic and anti-inflammatory effects. MRS4654 can be used for research on asthma and neuropathic pain.
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BMS-884775
0 ImagesCat. No.: HY-120612CAS No.: 1557206-59-3BMS-884775 is a selective and orally active P2Y1 antagonist with an IC50 of 0.1 nM for the human P2Y1 receptor. BMS-884775 has a similar efficacy in preventing arterial thrombosis to Clopidogrel (HY-15283) and Prasugrel (HY-15284), but treatment with BMS-884775 results in shorter bleeding time and lower bleeding risk. BMS-884775 can be used in research related to antiplatelet and arterial thrombosis-associated diseases.
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MRS4917
0 ImagesCat. No.: HY-178006MRS4917 is an orally active, potent selective P2Y14 receptor (hP2Y14R) antagonist (IC50 = 2.88 nM, Ki = 1.67 nM) that shows >18,000 fold selectivity against P2Y6R (IC50 = 54 μM). MRS4917 demonstrates oral efficacy in reversing established mechanoallodynia in the chronic constriction injury (CCI) mouse model, while having no effect on thermoregulation. MRS4917 can be used for neurological diseases research.
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ATP-γ-S tetrasodium
0 ImagesCat. No.: HY-134361CAS No.: 88453-52-5ATP-γ-S (tetrasodium) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATP-γ-S (tetrasodium) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATP-γ-S (tetrasodium) is active in ATP hydrolysis.
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PSB-22219
0 ImagesCat. No.: HY-174153CAS No.: 1404529-43-6PSB-22219 is a highly selective non-nucleotidic ligand acting on P2Y12 receptors (KD=4.57 nM). PSB-22219 is promising for research of P2Y12 receptor-associated neuroinflammation.
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UTPU trisodium
0 ImagesCat. No.: HY-177726CAS No.: 401618-61-9UTPU trisodium (Compound 19) is a selective P2Y6R agonist with an EC50 of 0.4 μM. UTPU trisodium can activate the intracellular calcium signaling pathway mediated by P2Y6. UTPU trisodium can be used for the research of inflammation.
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MRS-2179
0 ImagesCat. No.: HY-115273CAS No.: 101204-49-3MRS-2179 is a selective and competitive antagonist for P2Y1 receptor, with KB of 0.177 μM.
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P2ry2 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09929P2ry2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2ry2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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P2RY2 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09928P2RY2 Human Pre-designed siRNA Set A contains three designed siRNAs for P2RY2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
